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KMID : 0604520130390010009
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Journal of the Society of Cosmetic Scientists of Korea
2013 Volume.39 No. 1 p.9 ~ p.17
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Anti-oxidant and Anti-aging Activities of Sericinjam Gland Hydrolysate Extract in Human Dermal Fibroblasts
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Cheon Yu-Ri
Hwang Jung-Wook
Lee Heui-Sam
Yun Sei-Young
Choi Yong-Soo
Kang Sang-Jin
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Abstract
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We studied the anti-oxidant and anti-aging activities of Sericinjam Gland Hydrolysate (SJGH) in the human dermal fibroblasts. SJGH effectively defended cell death and ROS generation under high H2O2 in human dermal fibroblasts. Moreover SJGH reduced the expression of SA-β-Gal and MMP-1 under low concentration of H2O2 whereas biosynthesis of procollagen-Ⅰ was increased. This results demonstrate the anti-oxidant and anti-aging activities of SJGH. SJGH could be a good candidate for anti-aging cosmetics ingredient.
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KEYWORD
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Sericinjam, procollagen I, MMP-1, fibroblast, oxidative damage
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